R&D Center

Research field and Performance

L&C BIO Research Center is contributing to the improvement of the quality of human life by developing and supplying innovative healthcare solutions in various fields, including tissue engineering, medical devices and cosmeceuticals, in cooperation with medical professionals.


  • Allograft Technology
  • Asia No.1 Tissue Bank.
    Development of acellural dermal matrix and allogenic bone with various tissue regeneration and tissue reconstruction techniques
  • Xenograft Technology
  • Development of application technology of acellular dermal matrix
  • Medical Device Technology
  • Based on L&C BIO’s original human body tissue processing technology, we developed different human tissue-based medical device manufacturing technology, such as biomaterials for tissue repair, collagen-based tissue supplement materials, biomaterials, biomaterial bones for implantation, deep body wound covering material, bioabsorbable wound covering materials, and absorbable, in-body, hemostatic supplies used in body insertion.
  • Drug Delivery Technology
  • Development of manufacturing technology of implantable medical device using drug delivery technology

Patent registration

  • Jig for freeze-drying a dermal tissue (No. 10-1395712)
  • Dermal tissue graft with the basement membrane layer removed (No. 10-1362402)
  • Dermal tissue graft with multiple penetration formation (No. 10-1362403)
  • Cross-linking manufacturing of particle-type acellular dermis and hyaluronic acid through an electron beam (No. 10-1523878)
  • Manufacturing method of a composition for cross-linking, living body implantation, or insertion of acellular dermis(No. 10-1650273)
  • Manufacturing method of a composition for living body implantation, in which the particle-type acellular dermis and the hyaluronic acid are cross-linked (No. 10-1729127)
  • Acellular Dermal Matrix used multi penetration (9532866, USA)

Carry out government task

  • Selected as a technology innovation development project (Small and Medium Business Administration, 2013)
    : Project name _ Development of heterogeneous acellular dermis using non-septic manipulation technique and different dermis processing technique
  • Selected as a technology development project related to medical diagnosis (Small and Medium Business Administration, 2013)
    : Title _ Development of homogenous dermis with enhanced bio-preservability by particle type and crosslinking technology
  • Selected as a G-STAR enterprise promotion project (Gyeonggi-do, 2013)
    : Project name _ Development of skin substitute materials using Korean pork
  • Support for SME technology development - Selected as a technology development project linking overseas demand sources (Small and Medium Business Administration, 2014)
    : Project name _ Development of non-cell homogenous dermis and filler with 50% increase in biocompatibility and preservability by crosslinking with hyaluronic acid
  • Support for SME technology development - Selected as a technology innovation development project (Small and Medium Business Administration, 2015)
    : Project name _ Development of next generation thermosensitive gel type adhesion inhibitor to form collagen-based biodegradable barrier
  • Selected as a technology development project of Gyeonggi-do (Gyeonggi-do, Gyeonggi-do Economic Science Promotion Agency, 2016)
    : Project name _ Development of high purity human collagen for the treatment of pain and osteoarthritis
  • Selected as an innovative technology development business (Small and Medium Business Administration, 2017)
    : Project name _ Development of a hydration-type cell-free allogeneic dermis medical device optimized for breast reconstruction following breast cancer surgery

Product Reference

  • Characterization and tissue incorporation of cross-linked human acellular dermal matrix
    Ju Hee Lee et al. Biomaterials (2015) 44:195-205
  • Preventive effect of human acellular dermal matrix on post-thyroidectomy scars and adhesions
    Kee Hyun Nam et al. Dermatologic Surgery (2015) 41:812`820
  • Esthetic neck dissection using an endoscope via retroauricular incision
    Woong Nam et al. J Korean Assoc Oral Maxillofac Surgery (2014) 40:27-31
  • Acceleration of osteogenesis by platelet-rich plasma with acellular dermal matrix in a calvarial defect model
    Woon Hyeok Jeong et al. Childs Nerv Syst (2016) 32:1653–1659
  • The effects of a multigrowth factor-containing cream on recovery after laser treatment
    Sung Sik Shin et al. Journal of Cosmetic Dermatology (2016) 0:1-8
  • Acellular Dermal Matrix as a Core Strut for Projection in Nipple Reconstruction: Approaches for Three Different Methods of Breast Reconstruction
    Gui-Yong Park et al. Archives of Plastic Surgery (2016) 43:424-429
  • Augmentation Rhinoplasty With Silicone Implant Covered With Acellular Dermal Matrix in Asian Noses
    Man Koon Suh et al. The Journal of Craniofacial Surgery (2016)
  • The Effect of Sterile Acellular Dermal Matrix Use on Complication Rates in Implant-Based Immediate Breast Reconstructions
    Jun Ho Lee et al. Archives of Plastic Surgery (2016) 43:523-528
  • Comparative Skin Evaluation After Split-Thickness Skin Grafts Using 2 Different Acellular Dermal Matrices to Cover Composite Forearm Defects
    Myung Chul Lee et al. J Hand Surg Am. (2017)
  • Use of Acellular Allogenic Dermal Matrix (MegaDerm) in Orbital Wall Reconstruction: A Comparison With Absorbable Mesh Plate and Porous Polyethylene
    Jiye Kim et al. The Journal of Craniofacial Surgery (2017)
  • Comparison of the Amount of Drainage in 3 Acellular Dermal Matrices in Implant-Based Breast Reconstruction: A Retrospective Study
    Jiye Kim et al. The Journal of Craniofacial Surgery (2017)
  • Micronized Cross-Linked Human Acellular Dermal Matrices: An Effective Scaffold for Collagen Synthesis and Promising Material for Tissue Augmentation
    Tae Hwan Park et al. Tissue Eng Regen Med (2017) 14(5):517–523
  • Usefulness of Cross-Linked Human Acellular Dermal Matrix as an Implant for Dorsal Augmentation in Rhinoplasty
    Chae Eun Yang et al. Aesth Plast Surg (2017)