R&D Center

Research field and Performance

L&C BIO Research Center is contributing to the improvement of the quality of human life by developing and supplying innovative healthcare solutions in various fields, including tissue engineering, medical devices and cosmeceuticals, in cooperation with medical professionals.


  • Allograft Technology
  • Asia No.1 Tissue Bank.
    Development of acellural dermal matrix and allogenic bone with various tissue regeneration and tissue reconstruction techniques
  • Xenograft Technology
  • Development of application technology of acellular dermal matrix
  • Medical Device Technology
  • Based on L&C BIO’s original human body tissue processing technology, we developed different human tissue-based medical device manufacturing technology, such as biomaterials for tissue repair, collagen-based tissue supplement materials, biomaterials, biomaterial bones for implantation, deep body wound covering material, bioabsorbable wound covering materials, and absorbable, in-body, hemostatic supplies used in body insertion.
  • Drug Delivery Technology
  • Development of manufacturing technology of implantable medical device using drug delivery technology

Patent registration

  • Jig for freeze-drying a dermal tissue (No. 10-1395712)
  • Dermal tissue graft with the basement membrane layer removed (No. 10-1362402)
  • Dermal tissue graft with multiple penetration formation (No. 10-1362403)
  • Cross-linking manufacturing of particle-type acellular dermis and hyaluronic acid through an electron beam (No. 10-1523878)
  • Manufacturing method of a composition for cross-linking, living body implantation, or insertion of acellular dermis(No. 10-1650273)
  • Manufacturing method of a composition for living body implantation, in which the particle-type acellular dermis and the hyaluronic acid are cross-linked (No. 10-1729127)
  • Acellular Dermal Matrix used multi penetration (9532866, USA)
  • Manufacturing Method of Thermosensitive Anti-adhesion Compositios Based on Micronized Acellular Dermal Matrix (No. 10-1845885)
  • Manufacturing Method of Soft Tissue Filler Composition Based on Hyaluronic Acid (No. 10-1886413)
  • The Method of High-yield and High-purity Manufacturing of Allo-collagen Composition Extracted From Human origin (No. 10-1916759)
  • Method for Manufacturing Biological Implants (No. 10-2040592)
  • ZAG Protein-Derived Peptides and Use Thereof (No. 10-2149202)

Carry out government task

  • Selected as a technology innovation development project (Ministry of SMEs and Startups, 2013)
    : Project name _ Development of heterogeneous acellular dermis using non-septic manipulation technique and different dermis processing technique
  • Selected as a technology development project related to medical diagnosis (Ministry of SMEs and Startups, 2013)
    : Title _ Development of homogenous dermis with enhanced bio-preservability by particle type and crosslinking technology
  • Selected as a G-STAR enterprise promotion project (Gyeonggi-do, 2013)
    : Project name _ Development of skin substitute materials using Korean pork
  • Support for SME technology development - Selected as a technology development project linking overseas demand sources (Ministry of SMEs and Startups, 2014)
    : Project name _ Development of non-cell homogenous dermis and filler with 50% increase in biocompatibility and preservability by crosslinking with hyaluronic acid
  • Support for SME technology development - Selected as a technology innovation development project (Ministry of SMEs and Startups, 2015)
    : Project name _ Development of next generation thermosensitive gel type adhesion inhibitor to form collagen-based biodegradable barrier
  • Selected as a technology development project of Gyeonggi-do (Gyeonggi-do, Gyeonggi-do Economic Science Promotion Agency, 2016)
    : Project name _ Development of high purity human collagen for the treatment of pain and osteoarthritis
  • Selected as an innovative technology development business (Ministry of SMEs and Startups, 2017)
    : Project name _ Development of a hydration-type cell-free allogeneic dermis medical device optimized for breast reconstruction following breast cancer surgery
  • Selected as Medi-Bio Product Technology Development and Clinical Trial Support Business (Seongnam Industry Promotion Agency, 2018)
    : Project Title _Double-blind, Multi-center randomization, prospective confirmatory clinical studies to evaluate the efficacy and safety of MegaShield using for anti-adhesion after total thyroidectomy
  • Selected as Export Company Technology Development Project (Ministry of SMEs and Startups, 2018)
    : Project Title _Development of Demineralized Bone Matrix Containing Human Bone Mineral and Hyaluronic Acid Carriers.
  • Selected as Medical Device Clinical Trial Support Project (Ministry of Health and Welfare, 2018)
    : Project Title _Clinical trial to evaluate the efficacy and safety of MegaShield
  • Selected as International Joint Technology Development Project (Ministry of Trade, Industry and Energy, 2019)
    : Project Title _Development of Next Generation Human Decellularized Nerve Adopted to a Noble Surgery for Neuronal Reconstruction in Peripheral Nerve Injury Patients
  • Selected as Korea Medical Device Development Fund Project (Korea Medical Device Development Fund, 2020)
    : Project Title _Clinical trial to evaluate the efficacy and safety of MegaCarti in Knee Cartilage Defects

Product Reference

  • Characterization and tissue incorporation of cross-linked human acellular dermal matrix
    Ju Hee Lee et al. Biomaterials (2015) 44:195-205
  • Preventive effect of human acellular dermal matrix on post-thyroidectomy scars and adhesions
    Kee Hyun Nam et al. Dermatologic Surgery (2015) 41:812`820
  • Esthetic neck dissection using an endoscope via retroauricular incision
    Woong Nam et al. J Korean Assoc Oral Maxillofac Surgery (2014) 40:27-31
  • Acceleration of osteogenesis by platelet-rich plasma with acellular dermal matrix in a calvarial defect model
    Woon Hyeok Jeong et al. Childs Nerv Syst (2016) 32:1653–1659
  • The effects of a multigrowth factor-containing cream on recovery after laser treatment
    Sung Sik Shin et al. Journal of Cosmetic Dermatology (2016) 0:1-8
  • Acellular Dermal Matrix as a Core Strut for Projection in Nipple Reconstruction: Approaches for Three Different Methods of Breast Reconstruction
    Gui-Yong Park et al. Archives of Plastic Surgery (2016) 43:424-429
  • Augmentation Rhinoplasty With Silicone Implant Covered With Acellular Dermal Matrix in Asian Noses
    Man Koon Suh et al. The Journal of Craniofacial Surgery (2016)
  • The Effect of Sterile Acellular Dermal Matrix Use on Complication Rates in Implant-Based Immediate Breast Reconstructions
    Jun Ho Lee et al. Archives of Plastic Surgery (2016) 43:523-528
  • Comparative Skin Evaluation After Split-Thickness Skin Grafts Using 2 Different Acellular Dermal Matrices to Cover Composite Forearm Defects
    Myung Chul Lee et al. J Hand Surg Am. (2017)
  • Use of Acellular Allogenic Dermal Matrix (MegaDerm) in Orbital Wall Reconstruction: A Comparison With Absorbable Mesh Plate and Porous Polyethylene
    Jiye Kim et al. The Journal of Craniofacial Surgery (2017)
  • Comparison of the Amount of Drainage in 3 Acellular Dermal Matrices in Implant-Based Breast Reconstruction: A Retrospective Study
    Jiye Kim et al. The Journal of Craniofacial Surgery (2017)
  • Micronized Cross-Linked Human Acellular Dermal Matrices: An Effective Scaffold for Collagen Synthesis and Promising Material for Tissue Augmentation
    Tae Hwan Park et al. Tissue Eng Regen Med (2017) 14(5):517–523
  • Usefulness of Cross-Linked Human Acellular Dermal Matrix as an Implant for Dorsal Augmentation in Rhinoplasty
    Chae Eun Yang et al. Aesth Plast Surg (2017)
  • Surgical Outcomes of Tympanoplasty Using Acellular Dermal Allograft: A Randomized Controlled Study
    Kim, Sung Huhn et al. ACTA OTORHINOLARYNGOLOGICA ITALICA (2018) 38:554-562
  • Homologous Tissue for Dorsal Augmentation
    Kim, Chang-Hoon, and Sang Chul Park. Facial Plastic Surgery Clinics of North America (2018) 26(3):311-321
  • Dual Coverage of the Inferior Pole with Conjoined Fascial Flap and Acellular Dermal Matrix for Immediate One-Stage Breast Reconstruction with a Prosthetic Implant
    Seo H. Lee et al. Aesthetic Plast Surg (2018) 42(5):1213-1219.
  • Development of novel biocompatible thermosensitive anti-adhesive agents using human-derived acellular dermal matrix
    Jeong, Jong Ju, et al. PloS one (2019) 14.2: e0212583
  • Cryptotia recurrence lowering technique with additional acellular dermal matrix graft. Archives of craniofacial surgery
    Lee, Dongeun, et al. Archives of craniofacial surgery (2019) 20(3):170-175
  • A comparative study between sterile freeze-dried and sterile pre-hydrated acellular dermal matrix in tissue expander/implant breast reconstruction
    Jeong Hyun Cheon et al. Archives of plastic surgery (2019) 46(3): 204-213
  • Effect of Biologic Material Reinforcement on Surgical Anastomosis After Gastrectomy—A Pilot Study
    Won Jun Kim et al. Frontiers in Oncology (2019) 9:1184
  • Short-term changes of human acellular dermal matrix (Megaderm) in a mouse model
    Yang Seok Kim et al. ACFS(Archives of Craniofacial Surgery) (2019) 20(1):10–16
  • Volume replacement with diced acellular dermal matrix in oncoplastic breastconserving surgery: a prospective singlecenter experience
    Hongki Gwak et al. World Journal of Surgical Oncology (2020) 18:1-7
  • Comparison of Volume Retention and Biocompatibility of Acellular Dermal Matrix/Hyaluronic Acid Filler to Autologous Fat Grafts in a Mouse Model
    Ji Hun Kim et al. Aesthetic Plastic Surgery (2020) 44(3):986-992
  • Funnel usefulness in direct-to-implant breast reconstruction using periareolar incision with prepectoral implant placement and complete coverage with acellular dermal matrix
    Woo, Joohyun, Ik Hyun Seung, and Seung Eun Hong. JPRAS (journal of plastic,reconstructive & aesthetic surgery) (2020) 73(11):2016-2024
  • The relationship of human acellular dermal matrix thickness on complication rate and patient-reported outcomes in implant-based immediate breast reconstruction
    Hong, Seung Eun, and Jung-Hoon Kim. Gland Suregery (2021) 10(1):90-100
  • Comparison of irradiated and non-irradiated acellular dermal matrices in breast reconstruction under radiotherapy
    Woo, Soo Jin, Jeong Hyun Ha, and Ung Sik Jin. Archives of Plsatic surgery (2021) 48(1): 33–43
  • Effect of human acellular dermal matrix (Megaderm™) on infra-auricular depressed deformities, Frey’s syndrome, and first
    Joo Hyun Kim et al. Gland Suregery (2021) 10(2):670-677
  • Predictive factors of drainage volume and drain duration after the inframammary approach to nipple-areolar-complex sparing mastectomy and implant-based breast reconstruction
    Yoon Soo Kim et al. archives of aesthetic plastic surgery (2021) 27(1):23-30
  • A comparative study of pre- or subpectoral expander position with the fenestrated Acellular dermal matrix anterior coverage, on drainage volume and Seroma Formation after Non-Nipple-Sparing Mastectomy
    Suh, Young Chul, et al. JPRAS (journal of plastic,reconstructive & aesthetic surgery) (2021)
  • Nasal alar rim redraping method to prevent alar retraction in rhinoplasty for Asian men: A retrospective case series
    Choi, Jun Ho, Hyokyung Yoo, and Byung Jun Kim. Archives of Plastic surgery (2021) 48(1):3